Skulls are among the strongest of all non-boss/mini boss enemies in the game. They appear exclusively in Chapter 5, first showing up near the end of City on Water and in Docks. They look like humans that wear skulls on their head with long, black hair. They wear grey jackets without shirts, and have odd gauntlets on their arms. They wear thick boots, and wield sawn-off shotguns for combat. These brutes attack mainly by shooting you with their shotgun. This does a LOT of damage on higher difficulties, and they have a huge amount of health too. (It takes 2 stakes to kill them on DAYDREAM.) In City on Water they can also use handy enemies nearby, such as Hell Bikers, as meat shields as they slowly strafe around and pound you with buckshot. The best way to deal with them is to hit them with heavy weapons such as the Stake Gun, Rockets, or chaingun ammo. If desperate, use the Freezer on them, as this kills them in one hit. Later in Docks they have a desperation move where they blow their own head off and become invincible for a bit. You can tell if you see flames coming out of their head. They're even immune to being shattered by freezing. If they use an enemy as a meat shield, try to use explosives and take them both out. Their souls are the rare red souls, and they recover 6 HP instead of the green soul's 1.